Consumption coagulopathy associated with systemic juvenile rheumatoid arthritis
Identifieur interne : 003673 ( Main/Exploration ); précédent : 003672; suivant : 003674Consumption coagulopathy associated with systemic juvenile rheumatoid arthritis
Auteurs : Earl D. Silverman [États-Unis] ; John J. Miller Iii [États-Unis] ; Bram Bernstein [États-Unis] ; Turaj Shafai [États-Unis]Source :
- The Journal of Pediatrics [ 0022-3476 ] ; 1983.
English descriptors
- Teeft :
- Active disease, Active polyarthritis, Arthritis, Arthritis rheum, Aspirin, Aspirin hepatotoxicity, Blood cells, Blood smear, Burr cells, Coagulation, Coagulopathy, Consumption coagulopathy, Corticosteroid therapy, Disease activity, Drug treatment, Fibrin split products, Hemoglobin level, High doses, Indomethacin, Intravascular, Intravascular coagulation, Laboratory values, Liver disease, Nonsteroidal, Nonsteroidal drugs, Other nonsteroidal drugs, Pediatrics december, Platelet, Platelet aggregation, Platelet count, Platelet cyclooxygenase, Prednisone therapy, Rash, Rheumatoid arthritis, Second group, Second injection, Serum albumin concentration, Serum albumin concentrations, Serum salicylate concentration, Systemic, Systemic symptoms, Unbound drugs, White girl.
Abstract
A coagulopathy resembling disseminated intravascular coagulation may occur in systemic juvenile rheumatoid arthritis. We have seen this in seven patients with three different circumstances of disease activity or drug treatment. In one patient, a coagulopathy was not associated with drug therapy, and required corticosteroid therapy for control. A second group of patients was receiving orally nonsteroidal anti-inflammatory drugs during an acute flare-up of disease associated with low serum albumin concentrations. Coagulopathy in these patients may be a result of reduced vascular endothelial cell cyclooxygenase activity secondary to increased levels of unbound nonsteroidal anti-inflammatory drug. In these children, corticosteroid therapy was required for control. A third form of coagulopathy was seen in patients receiving a second injection of aurothiomalate. This form appears to be idiosyncratic, self-limiting, and relatively benign.
Url:
DOI: 10.1016/S0022-3476(83)80704-5
Affiliations:
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sort="Bernstein, Bram" uniqKey="Bernstein B" first="Bram" last="Bernstein">Bram Bernstein</name><affiliation wicri:level="3"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Children's Hospital at Stanford, Stanford University School of Medicine, Stanford, Los Angeles</wicri:regionArea><placeName><settlement type="city">Los Angeles</settlement><region type="state">Californie</region></placeName></affiliation><affiliation wicri:level="3"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Rheumatology and Rehabilitation, Children's Hospital of Los Angeles, Stanford, Los Angeles</wicri:regionArea><placeName><settlement type="city">Los Angeles</settlement><region type="state">Californie</region></placeName></affiliation><affiliation wicri:level="1"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pediatrics, Riverside General Hospital and University Medical Center, Riverside</wicri:regionArea><wicri:noRegion>Riverside</wicri:noRegion></affiliation></author><author><name sortKey="Shafai, Turaj" sort="Shafai, Turaj" uniqKey="Shafai T" first="Turaj" last="Shafai">Turaj Shafai</name><affiliation wicri:level="3"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Children's Hospital at Stanford, Stanford University School of Medicine, Stanford, Los Angeles</wicri:regionArea><placeName><settlement type="city">Los Angeles</settlement><region type="state">Californie</region></placeName></affiliation><affiliation wicri:level="3"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Rheumatology and Rehabilitation, Children's Hospital of Los Angeles, Stanford, Los Angeles</wicri:regionArea><placeName><settlement type="city">Los Angeles</settlement><region type="state">Californie</region></placeName></affiliation><affiliation wicri:level="1"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pediatrics, Riverside General Hospital and University Medical Center, Riverside</wicri:regionArea><wicri:noRegion>Riverside</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">The Journal of Pediatrics</title><title level="j" type="abbrev">YMPD</title><idno type="ISSN">0022-3476</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1983">1983</date><biblScope unit="volume">103</biblScope><biblScope unit="issue">6</biblScope><biblScope unit="page" from="872">872</biblScope><biblScope unit="page" to="876">876</biblScope></imprint><idno type="ISSN">0022-3476</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0022-3476</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Active disease</term><term>Active polyarthritis</term><term>Arthritis</term><term>Arthritis rheum</term><term>Aspirin</term><term>Aspirin hepatotoxicity</term><term>Blood cells</term><term>Blood smear</term><term>Burr cells</term><term>Coagulation</term><term>Coagulopathy</term><term>Consumption coagulopathy</term><term>Corticosteroid therapy</term><term>Disease activity</term><term>Drug treatment</term><term>Fibrin split products</term><term>Hemoglobin level</term><term>High doses</term><term>Indomethacin</term><term>Intravascular</term><term>Intravascular coagulation</term><term>Laboratory values</term><term>Liver disease</term><term>Nonsteroidal</term><term>Nonsteroidal drugs</term><term>Other nonsteroidal drugs</term><term>Pediatrics december</term><term>Platelet</term><term>Platelet aggregation</term><term>Platelet count</term><term>Platelet cyclooxygenase</term><term>Prednisone therapy</term><term>Rash</term><term>Rheumatoid arthritis</term><term>Second group</term><term>Second injection</term><term>Serum albumin concentration</term><term>Serum albumin concentrations</term><term>Serum salicylate concentration</term><term>Systemic</term><term>Systemic symptoms</term><term>Unbound drugs</term><term>White girl</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">A coagulopathy resembling disseminated intravascular coagulation may occur in systemic juvenile rheumatoid arthritis. We have seen this in seven patients with three different circumstances of disease activity or drug treatment. In one patient, a coagulopathy was not associated with drug therapy, and required corticosteroid therapy for control. A second group of patients was receiving orally nonsteroidal anti-inflammatory drugs during an acute flare-up of disease associated with low serum albumin concentrations. Coagulopathy in these patients may be a result of reduced vascular endothelial cell cyclooxygenase activity secondary to increased levels of unbound nonsteroidal anti-inflammatory drug. In these children, corticosteroid therapy was required for control. A third form of coagulopathy was seen in patients receiving a second injection of aurothiomalate. This form appears to be idiosyncratic, self-limiting, and relatively benign.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Californie</li></region><settlement><li>Los Angeles</li></settlement></list><tree><country name="États-Unis"><region name="Californie"><name sortKey="Silverman, Earl D" sort="Silverman, Earl D" uniqKey="Silverman E" first="Earl D." last="Silverman">Earl D. Silverman</name></region><name sortKey="Bernstein, Bram" sort="Bernstein, Bram" uniqKey="Bernstein B" first="Bram" last="Bernstein">Bram Bernstein</name><name sortKey="Bernstein, Bram" sort="Bernstein, Bram" uniqKey="Bernstein B" first="Bram" last="Bernstein">Bram Bernstein</name><name sortKey="Bernstein, Bram" sort="Bernstein, Bram" uniqKey="Bernstein B" first="Bram" last="Bernstein">Bram Bernstein</name><name sortKey="Miller Iii, John J" sort="Miller Iii, John J" uniqKey="Miller Iii J" first="John J." last="Miller Iii">John J. Miller Iii</name><name sortKey="Miller Iii, John J" sort="Miller Iii, John J" uniqKey="Miller Iii J" first="John J." last="Miller Iii">John J. Miller Iii</name><name sortKey="Miller Iii, John J" sort="Miller Iii, John J" uniqKey="Miller Iii J" first="John J." last="Miller Iii">John J. Miller Iii</name><name sortKey="Shafai, Turaj" sort="Shafai, Turaj" uniqKey="Shafai T" first="Turaj" last="Shafai">Turaj Shafai</name><name sortKey="Shafai, Turaj" sort="Shafai, Turaj" uniqKey="Shafai T" first="Turaj" last="Shafai">Turaj Shafai</name><name sortKey="Shafai, Turaj" sort="Shafai, Turaj" uniqKey="Shafai T" first="Turaj" last="Shafai">Turaj Shafai</name><name sortKey="Silverman, Earl D" sort="Silverman, Earl D" uniqKey="Silverman E" first="Earl D." last="Silverman">Earl D. Silverman</name><name sortKey="Silverman, Earl D" sort="Silverman, Earl D" uniqKey="Silverman E" first="Earl D." last="Silverman">Earl D. Silverman</name><name sortKey="Silverman, Earl D" sort="Silverman, Earl D" uniqKey="Silverman E" first="Earl D." last="Silverman">Earl D. Silverman</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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